Biopharmaceuticals: Advances in Protein Engineering and Therapeutic Applications

Résumé

Biopharmaceuticals, derived from living organisms, have revolutionized the treatment of numerous diseases. Protein engineering, a cornerstone of biopharmaceutical development, empowers scientists to manipulate protein structure and function, leading to the creation of novel therapeutics with enhanced efficacy and safety. This review delves into the cutting-edge advancements in protein engineering techniques, including rational design, directed evolution, and computational modeling. These strategies enable the optimization of protein stability, solubility, immunogenicity, and pharmacokinetic properties. Furthermore, the integration of protein engineering with emerging technologies like synthetic biology and nanotechnology has opened up new avenues for the development of sophisticated biotherapeutics. The therapeutic applications of engineered proteins are vast, ranging from monoclonal antibodies for cancer treatment to recombinant enzymes for metabolic disorders. As our understanding of protein structure and function deepens, the potential of protein engineering to address unmet medical needs continues to grow, promising a future of transformative therapies.