Mitochondrial Dysfunction and Disease: Unraveling the Biochemical Pathways Involved

Resumen

Mitochondria, the cell's powerhouses, play a crucial role in energy production and cellular homeostasis. Mitochondrial dysfunction, resulting from genetic mutations, environmental factors, or aging, disrupts these vital processes, leading to a wide range of diseases. This review delves into the intricate biochemical pathways underlying mitochondrial dysfunction and its association with various diseases. We explore the mechanisms by which mitochondrial dysfunction affects cellular metabolism, oxidative stress, and cell signaling pathways. Additionally, we discuss the emerging therapeutic strategies targeting mitochondrial dysfunction, including antioxidants, metabolic modulators, and gene therapy. A comprehensive understanding of the biochemical pathways involved in mitochondrial dysfunction is essential for developing effective therapeutic interventions and improving patient outcomes.